Anti-inflammatory and Analgesic activities of root and stem of cissus rependa vahl

Anti-inflammatory and analgesic activity of root and stem of Cissus rependa Vahl.(Vitaceae), a folklore medicinal plant of Gandhamardana hill ranges of Orissa, was carried out on albino rats and mice at the dose of 180 mg/kg and 260 mg/kg respectively. The effect on inflammation was studied on carrageenan and formalin induced paw oedema models and compared with phenylbutazone and diclofenac sodium standards respectively. Analgesic activity was evaluated in formalin induced paw licking and tail flick method where indomethacin and pentazocine were used as standard drugs respectively. The C. rependa root (CRR) significantly inhibited carrageenan induced paw oedema, formalin induced paw licking and prolonged tail flick response, however it was failed to suppress the formalin induced paw oedema, whereas C. rependa stem (CRS) significantly inhibited carrageenan induced paw oedema and formalin induced paw oedema at 24h, however it failed to inhibit formalin induced pain response. Further, CRS prolonged tail flick response significantly only at 180minutes. The results suggest that the root of C rependa has significant analgesic and anti-inflammatory potential as reflected by the parameters investigated, while stem has weak anti-inflammatory and analgesic activity. Thus it can be concluded that roots of C rependa have significant anti-inflammatory and analgesic activity and can be preferred in the treatment of pain and inflammation.