Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2496814 | Phytomedicine | 2012 | 4 Pages |
Abstract
The ethanolic extract and fractions of Wrightia tomentosa Roem. & Schult (Apocynaceae) leaves were tested in vivo for their antidyslipidemic activity in high fat diet (HFD) induced dyslipidemic hamsters. Activity guided isolation resulted in identification of antidyslipidemic compounds β-AA and β-AP. Compounds β-AA and β-AP decrease the levels of LDL by 36% and 44%, and increase the HDL-C/TC ratio by 49% and 28%, respectively, at a dose of 10 mg/kg. In addition, the isolated compounds β-AA and β-AP showed significant HMG-CoA-reductase inhibition, which was further established by docking studies.
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Authors
Ranjani Maurya, Anuj Srivastava, Priyanka Shah, Mohammad Imran Siddiqi, S.M. Rajendran, Anju Puri, Prem P. Yadav,