Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2497099 | Phytomedicine | 2010 | 5 Pages |
Abstract
Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.
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Authors
M.D. Lucas-Filho, G.C. Silva, S.F. Cortes, T.R. Mares-Guia, V. Perpétua Ferraz, C.P. Serra, F.C. Braga,