| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2497294 | Phytomedicine | 2009 | 6 Pages |
Abstract
Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC50 1.01 μg/ml) followed by caratuberside C (IC50 1.85 μg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity.
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Authors
Essam Abdel-Sattar, Naglaa G. Shehab, Chikara Ichino, Hiroaki Kiyohara, Aki Ishiyama, Kazuhiko Otoguro, Satoshi Omura, Haruki Yamada,