Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2497317 | Phytomedicine | 2009 | 5 Pages |
Abstract
Forsythide (F1) isolated from the leaves of Forsythia viridissima (Oleaceae) showed vasorelaxant effects on norepinephrine (NE)-induced contraction of rat aorta with or without endothelium. This compound did not affect contraction induced by high concentration potassium (60 mM K+) and phorbol 12,13-diacetate, but inhibited NE-induced contraction in the presence of nicardipine. These results demonstrated the inhibitory effects of F1 on NE-induced vasocontraction presumably due to decrease of calcium influx from extracellular area, which was induced by NE.
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Authors
T. Iizuka, H. Sakai, H. Moriyama, N. Suto, M. Nagai, D. Bagchi,