| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2497532 | Phytomedicine | 2009 | 5 Pages |
Abstract
The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity (IC50 0.01 μM). Duguetine and duguetine β-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC50 9.32 μM) than other alkaloids tested.
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Authors
D.B. da Silva, E.C.O. Tulli, G.C.G. Militão, L.V. Costa-Lotufo, C. Pessoa, M.O. de Moraes, S. Albuquerque, J.M. de Siqueira,