Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2497556 | Phytomedicine | 2008 | 5 Pages |
Abstract
Sesquiterpene glycoside, nerolidol-3-O-α-l-rhamnopyranosyl(1→4)-α-l-rhamnopyranosyl(1→2)-[α-l-rhamnopyranosyl(1→6)]-β-d-glucopyranoside was isolated from dried leaves of loquat [Eriobotrya japonica (Thunb.) Lindl., Rosaceae]. Hypoglycemic effects of this natural product were assessed in normal and alloxan-diabetic mice model. Animals received orally administration of the sesquiterpene glycoside in dose of 25 and 75 mg/kg. The anti-hyperglycemic effect was compared with gliclazide's. The dose of 25 and 75 mg/kg both exerted a significant (p<0.05p<0.05) hypoglycemic effect in alloxan-diabetic mice throughout the test and a slight effect in normal mice.
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Authors
J. Chen, W.L. Li, J.L. Wu, B.R. Ren, H.Q. Zhang,