Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2497567 | Phytomedicine | 2006 | 6 Pages |
Abstract
Using field potential recording in the CA1 region of the rat hippocampal slices, the effects of eugenol on synaptic transmission and long-term potentiation (LTP) were investigated. Population spikes (PS) were recorded in the stratum pyramidal following stimulation of stratum fibers. To induce LTP, eight episodes of theta pattern primed-bursts (PBs) were delivered. Eugenol decreased the amplitude of PS in a concentration-dependent manner. The effect was fast and completely reversible. Eugenol had no effect on PBs-induced LTP of PS. It is concluded that while eugenol depresses synaptic transmission it does not affect the ability of CA1 synapses for tetanus-induced LTP and plasticity.
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Authors
A. Ardjmand, Y. Fathollahi, M. Sayyah, M. Kamalinejad, A. Omrani,