| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2497568 | Phytomedicine | 2006 | 5 Pages |
Abstract
The phytochemical investigation of Trichodesma amplexicaule guided by bioassay, to isolation of triterpenoids and aliphatic phytoconstituents. To evaluate the anti-inflammatory activities of isolated phytoconstituents, models with carrageenan-induced acute arthritis and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The investigated results showed that alkanoic acid significantly inhibited the carrageenan-induced acute arthritis. Moreover, alkane also supressed the development of chronic arthritis induced by CFA. It has been reported that alkane was the major phytoconstituent (1.03±0.00135%) in in vivo studies.
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Authors
B. Singh, P.M. Sahu, R.K. Lohiya, M.K. Sharma, H.L. Singh, S. Singh,