Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2497956 | Phytomedicine | 2008 | 4 Pages |
Abstract
A white solid compound was isolated from the chloroform extract of the leaves of Senna villosa. The material was identified by 1H-NMR, 13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested in vitro at concentrations of 1.65, 3.3 and 6.6 μg/ml for inhibition of the growth of Trypanosoma cruzi epimastigotes and tripomastigotes. We observed inhibition of growth at all concentrations tested, and the effect at concentrations of 3.3 and 6.6 μg/ml was greater than that of gentian violet (positive control). At the concentration of 6.6 μg/ml, the compound showed the greatest inhibitory effect against the growth of both forms of the parasite.
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Authors
E. Guzmán, C. Pérez, M.A. Zavala, K.Y. Acosta-Viana, S. Pérez,