| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2498199 | Phytomedicine | 2006 | 5 Pages |
Abstract
The antimicrobial activity of 10 natural abietanes isolated from Plectranthus grandidentatus and P. hereroensis acetonic extract was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The results revealed that the most active diterpenes were coleon U (1), 7α-acetoxy-6β-hydroxyroyleanone (2) and horminone (3). Minimum inhibitory concentration (MIC) values ranging 0.98–15.63 μg/ml were obtained for MRSA clinical strains, and MIC values of 15.63 and 31.25 μg/ml were obtained for VRE clinical strains. Some structure–activity relationships are emphasized.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Clinical Biochemistry
Authors
C. Gaspar-Marques, P. Rijo, M.F. Simões, M.A. Duarte, B. Rodriguez,