| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2510283 | Antiviral Research | 2011 | 5 Pages |
Abstract
A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease.
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Authors
Suki M.Y. Lee, W.W. Gai, Timothy K.W. Cheung, J.S.M. Peiris,