Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2510811 | Antiviral Research | 2009 | 5 Pages |
Abstract
Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
Keywords
Related Topics
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Immunology and Microbiology
Virology
Authors
Gui-Feng Wang, Li-Ping Shi, Yu-Dan Ren, Qun-Fang Liu, Hou-Fu Liu, Ru-Jun Zhang, Zhuang Li, Feng-Hua Zhu, Pei-Lan He, Wei Tang, Pei-Zhen Tao, Chuan Li, Wei-Min Zhao, Jian-Ping Zuo,