Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2511139 | Antiviral Research | 2008 | 4 Pages |
Abstract
In this study the antiviral activity of a panel of 18 out of 240 pyridazinamine analogues was evaluated against the Sabin strains of the three poliovirus types. We found one compound, R75761 which had a comparable 50% effective concentration (EC50) value against all three poliovirus Sabin strains. Virus multiplication was reduced by 104.0-fold, 106.2-fold and 106.6-fold for poliovirus type 1, type 2 and type 3, respectively. R75761 could be considered as a lead compound for development of anti-poliovirus drugs to be used during the late stage of poliovirus eradication and beyond.
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Authors
Bert Thys, Armando M. De Palma, Johan Neyts, Koen Andries, Raf Vrijsen, Bart Rombaut,