Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2511304 | Antiviral Research | 2008 | 4 Pages |
Abstract
Drug-resistant herpes simplex virus type 1 (HSV-1) recombinant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes were evaluated for their susceptibility to various antivirals in the presence of 25 μg/ml of hydroxyurea (HyU). The latter compound decreased the 50% inhibitory concentrations of acyclovir by 1.5–3.8-fold and that of cidofovir by 2.7–14.4-fold. However, HyU did not affect the susceptibilities of the various recombinant mutants to foscarnet. Hydroxyurea, a ribonucleotide reductase inhibitor, can increase the activity of nucleoside/nucleotide analogues against drug-resistant viruses.
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Authors
Yan Sergerie, Guy Boivin,