Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2523740 | Biomedicine & Pharmacotherapy | 2016 | 6 Pages |
Abstract
MicroRNAs (miRNAs) regulate gene expression and are involved in cervical cancer. But the molecular mechanism is still unclear. Here, miRNA profile of cervical cancer was performed and demonstrated that miR-486-3p decreased in specimens of cervical cancer patients. In addition, our clinical data show that decreased miR-486-3p was associated with metastasis in cervical cancer patients. ECM1 was predicted and velified as a target gene of miR-486-3p. Overexpression of miR-486-3p inhibited cell growth and metastasis by targeting ECM1. In a conclusion, these findings suggest that miR-486-3p is a tumor suppressor miRNA and induction of miR-486-3p is a potential strategy to inhibit cervical cancer progression.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Oncology
Authors
Haiqiong Ye, Xiaolan Yu, Jiyi Xia, Xiaoping Tang, Li Tang, Feng Chen,