Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2523943 | Biomedicine & Pharmacotherapy | 2015 | 9 Pages |
Abstract
Physical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these tests, the comet assay (CA) and micronucleus assay (MNA) are the most commonly used. However, there are different protocols and recommendations already published. This is the first review, after the inclusion of CA in S2R1 guidance and OECD 489, which summarizes the main technical recommendations of both CA and MNA.
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Authors
Rodrigo Pinheiro Araldi, Thatiana Corrêa de Melo, Thais Biude Mendes, Paulo Luiz de Sá Júnior, Bruno Heidi Nakano Nozima, Eliana Tiemi Ito, Rodrigo Franco de Carvalho, Edislane Barreiros de Souza, Rita de Cassia Stocco,