| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2524161 | Biomedicine & Pharmacotherapy | 2015 | 6 Pages |
Abstract
In this study we investigate the role of CC motif chemokine ligand 19 (CCL19) to colorectal cancer (CRC) in vivo. We injected different dose of recombinant mouse CCL19 (rmCCL19) in the tumor site of the model of transplanted tumor. Result shows that rmCCL19 can suppress CRC tumorigenesis and growth in vivo, and it can also prolong overall survival of mice. Quantitative reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay results showed that the interferon-γ (IFN-γ) and interleukin-12 (IL-12) levels in the tumors and plasma were significantly enhanced after processing with rmCCL19.
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Authors
Jun Lu, Junjun Ma, Wei Cai, Xiongzhi Wangpu, Hao Feng, Jingkun Zhao, Shaopei Guan, Yaping Zong, Aiguo Lu,