| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2525074 | Biomedicine & Pharmacotherapy | 2010 | 9 Pages |
Abstract
We have shown that glucosaminyl muramyl dipeptide (GMDP) has been augmented the antitumor action of chemotherapy drug cisplatin and tumor necrosis factor-α (TNFα) on the Ehrlich ascites carcinoma and melanoma B-16 mouse tumor models. The doses of cisplatin, TNFα and GMDP and also the conditions of the drugs combination injection provided 100% survival of mice with Ehrlich ascites carcinoma were found. Furthermore, it was shown first that GMDP has been decreased toxicity of the cisplatin/TNFα combination and normalized the changes in the experimental mice hematological parameters which were produced by the CP/TNFα combination.
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Authors
Elena E. Petrova, Maria A. Simonova, Ravilya L. Komaleva, Marina V. Britsina, Tatiana M. Andronova, Vladimir A. Nesmeyanov, Tatiana I. Valyakina,