Synthesis and biological evaluation of decavanadate Na4Co(H2O)6V10O28·18H2O

We have reported the synthesis and biological evaluation of a decavanadate Na4Co(H2O)6V10O28·18H2O (CoV10) designed as a potential antitumoral agent. The human cancer cell lines SMMC-7721 (liver cancer) and SK-OV-3 (ovary cancer) were tested for their viability by the MTT method in vitro, which showed that the compound exhibited a remarkable activity against two cell lines with IC50 values smaller than 0.24 μg/mL, 0.32 μg/mL, respectively. CoV10 showed the tumor growth suppression for Hep-A-22 (mice liver cancer) in tumor bearing mice in vivo. In addition, using flow cytometry analysis, the ratio of apoptotic cells was up to 8.33% with treatment of CoV10 at 1.56 μg/mL after 30 min, suggesting that the antitumoral activity of CoV10 comes from the activation of the apoptotic pathway.