Pharmacokinetic, toxicological and phototherapeutic studies of phthalocyanine ZnPcCF3

ZnPcCF3 was accumulated in spleen, liver and duodenum. It suggests that ZnPcCF3 is eliminated from the body via bile-gut. The phthalocyanine was not found in brain, therefore, it would not cross the blood-brain barrier, thus toxicity risk in the central nervous system is not probable. Moreover, ZnPcCF3 does not accumulate in skin, it would eliminate cutaneous photosensitizing risks. The dose of 0.2 mg/kg ZnPcCF3 resulted in a low acute toxicity with revertible damages, which indicates that this dose can be used for PDT. The tumor death was of 89% 4 days after PDT. It indicates that ZnPcCF3 would be effective in PDT.