Peripheral blood mononuclear cell NF-ÎºB p105 mRNA decreases during asthmatic attacks

Article ID	Journal	Published Year	Pages	File Type
2525687	Biomedicine & Pharmacotherapy	2008	6 Pages	PDF

Abstract

A drop in NF-ÎºB p105 during an asthma attack could result in increased NF-ÎºB activity. There is a possibility that a change in the NF-ÎºB p105 mRNA level might indicate some pathogenetic state in bronchial asthma attacks.

Keywords

NF-κB TIA IKK IκB CTR GM-CSF RHD HDAC ICAM-1 IgE mRNA LTB4 PBMC VCAM-1 G3PDH Peripheral blood mononuclear cell (PBMC)cDNA Complementary DNA IκB kinase messenger RNA Bronchial asthma EDTA Ethylenediaminetetraacetic acid turbidimetric immunoassay IgE, immunoglobulin E interleukin TAD radioallergosorbent test tumor necrosis factor-α Transcriptional activation domain rel-homology domain RAST Peripheral blood mononuclear cell Global Initiative for Asthma granulocyte–macrophage colony-stimulating factor TNF-α nuclear factor-κB Leukotriene B4 inhibitor of κB intercellular adhesion molecule-1 vascular cell adhesion molecule-1 polymerase chain reaction PCR C-reactive protein CRP glyceraldehyde-3-phosphate dehydrogenase GINA

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Health Sciences Medicine and Dentistry Oncology

Peripheral blood mononuclear cell NF-ÎºB p105 mRNA decreases during asthmatic attacks

Authors

Yasuhiro Matsumura,