| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2526617 | Chinese Journal of Natural Medicines | 2011 | 4 Pages |
Abstract
AimTo study the bioactive components of the rhizoma of Menispermum dauricum.MethodsRepeated column chromatography was used for the separation of the compounds and various spectroscopic techniques were applied for structural determination.ResultsEight compounds, meniscoside (1), dauricoside (2), dauriporphine (3), menisporphine (4), bianfugecine (5), 2, 3-dihydromenisporphine (6), syringaresinol (7), and syringaresinol 4, 4′-O-bis-glucoside (8) were obtained and identified. The effects on D1 and D2 receptors labeled with [3H] were evaluated.ConclusionCompound 1 was a new glucosidic benzylisoquinoline. Compounds 1-6 showed significant selective affinity to D1 receptor, and the IC50 of 1 and 2 were 9.2 and 2.0 μmol·L−1, respectively.
Related Topics
Health Sciences
Medicine and Dentistry
Complementary and Alternative Medicine
