A Novel Approach to Characterize Chemical Consistency of Traditional Chinese Medicine Fuzi Lizhong Pills by GC-MS and RRLC-Q-TOFMS

AimTo identify the chemical compositions of Fuzi Lizhong Pills, a traditional Chinese medicine that has been used for thousands of years in China.MethodsFingerprints of different batches of Fuzi Lizhong Pills were developed by gas chromatography-mass spectrometry (GC-MS) and rapid resolution liquid chromatography coupled with photo-diode array detector and time-of-flight mass spectrometry (RRLC-Q-TOFMS). Based on the fingerprints, the variation of the herbal prescription Fuzi Lizhong Pills was evaluated by hierarchical cluster analysis.ResultsWe have identified a total of 45 compounds in Fuzi Lizhong Pills with differences among samples from different companies.ConclusionThis work provides a method to identify the chemical compositions of Fuzi Lizhong Pills.