A Novel Ceramide from the Roots of Derris elliptica

AimTo study the chemical constituents from the roots of Derris elliptica (Roxb.) Benth.MethodsThe chemical constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analysis.ResultFour lipid constituents were obtained, including three ceramides, (2S, 3S, 4R, 8E)-2N-[(2′R, 3′)-2′, 3′-dihydroxyhexacosanoyl]-1, 3, 4-trihydroxy-8-octadecene (1), (2S, 3S, 4R, 8E)-2N-[(2′R)-2′-hydroxyhexacosanoyl]-1, 3, 4-trihydroxy-8-octadecene (2), 1-O−β-D-glucopyranosyl-(2S, 3S, 4R, 8E)-2N-[(2′R)-2′-hydroxytetracosanoyl]-3, 4-dihydroxy-8-octadecene (3), and a poly-hydroxyl octadecenoic acid, 12, 13, 15-trihydroxy-9-octadecenoic acid (4).ConclusionCompound 1 is a novel ceramide with hydroxyl group at C-3′, and is the first occurrence of ceramides with hydroxyl group at C-3′. Compounds 2–4 were isolated from genus Derris for the first time.