Sodium-dependent Glucose Transporter Was Involved in Salidroside Absorption in Intestine of Rats

AimTo report saturable absorption process of salidroside in rat intestine and investigate whether Na+-dependent glucose transporter (SGLT1) was involved in the absorption of salidroside.MethodRats orally received 12, 24 and 48 mg·kg− of salidroside, plasma concentrations were measured and corresponding pharmacokinetic parameters were estimated. Everted gut sleeves from the jejunum of rats were used for assaying the uptakes of salidroside in absences or presence of SGLT1 inhibitor phlorizin. Absorption of salidroside was investigated in diabetic rats induced by streptozotocin (STZ) and effective permeability coefficients in the jejunum of rats was carried out using in situ intestine perfusion.ResultsPlasma concentration-time profiles were completely overlapped, following oral dose 24 and 48 mg·kg−1 of salidroside, accompanied by similar pharmacokinetic parameters. Salidroside uptake by the rat everted gut sleeves was concentration-dependent and SGLTI inhibitor phlorizin might inhibit the uptake in a concentration-dependent manner. Salidroside was absorbed faster in gastro intestines of diabetic rats than it did in normal rats, accompanied by higher effective permeability coefficients.ConclusionSaturable absorption process of salidroside occurred in rat intestine and SGLT1 may be involved in the process of salidroside absorption.