| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2526853 | Chinese Journal of Natural Medicines | 2009 | 5 Pages |
Abstract
AimTo search for anti-HIV-1 metabolites from the cultures of helotialean ascomycete.MethodsHelotialins A-C (1-3) were purified from the crude extract using silica gel VLC, Sephadex LH-20 column chromatography, and reversed-phase HPLC. The structures of 1-3 were determined by NMR spectroscopy, and their absolute configurations were assigned by CD excitation chirality method.ResultsHelotialins A-C (1-3) were identified as three new azaphilone analogues.ConclusionCompounds 1 and 2 displayed inhibitory effects on HIV-1 replication in C8166 cells.
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