Two New Triterpenoid Saponins from the Roots ofGypsophila paniculata with Potent α-Glucosidase Inhibition Activity

AimTo investigate chemical constituents of Gypsophila paniculata.MethodsThe compounds were isolated by silica gel, Sephadex LH-20, Rp-C18 column chromatography and preparative liquid chromatography. Their structures were elucidated by ESI-MS, NMR techniques (1H, 13C, HMQC, HMBC, TOCSY) and acid hydrolysis. Moreover their α-glucosidase inhibition activity was evaluated compared with that of their aglycone.ResultsTwo triterpenoid saponins, caryophyllacosides A (1) and B (2), were isolated from the roots of Gypsophila paniculata, without having recourse to chemical degradation or modification. Both of them were found to have potent α-glucosidase inhibitiory activity.ConclusionThe two triterpenoid saponins are new boactive compounds.