| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2526933 | Chinese Journal of Natural Medicines | 2008 | 5 Pages |
ABSTRACTAIMTo establish a novel theory for the release/dissolution kinetics of the traditional Chinese medicines (TCMs) with the aim of the multi-component chemome.METHODSThe theory and method for the release/dissolution kinetics of the TCMs were established on the basis of the overall spectrum of the chemome of the TCMs. The released chemomic levels of TCMs were processed by Kalman filter method with stochastic simulation data as an illustration of the methodology feasibility.RESULTSMethodology study indicated that Kalman filter method was validated with good linearity, reproducibility, stability in calculation of the chemomic concentrations for the evaluation of the multi-component TCM release profile.CONCLUSIONKalman filter method is feasible for the evaluation of chemomic multi-component release/dissolution kinetics of TCMs, which is in line with the holistic theories of traditional Chinese medicine with illustrative visualization to simplify the massive results. The new theory shows methodological significance in optimal design of multi-component drug delivery systems of TCMs. A further study may be required to clarify the significance of the new method to pharmacokinetics and pharmacodynamics of TCM.
