Benefit-Risk Analysis of Glatiramer Acetate for Relapsing-Remitting and Clinically Isolated Syndrome Multiple Sclerosis

GA reduced relapses and clinical progression compared with placebo or standard treatment and clinical progression compared with IFNs. Serious adverse events were comparable in GA and IFNs. The BR assessments that were based on these data found that the clinical benefits of GA outweigh the risks, although results differ, depending on the quantitative BR model used, and are limited by the absence of reliable data for assigning weights to the model.