Immunopharmacological modulation of mast cells

•Mast cells play an important role in several pathophysiological conditions.•Several drugs modulate mast cell functions in vitro and/or in vivo.•The study of mast cell biology has suggested novel therapeutic targets.•The benefits versus the risks of mast cell-targeted drugs should be carefully evaluated.

Mast cells produce a wide spectrum of mediators and they have been implicated in several physiopathological conditions (e.g. allergic reactions and certain tumors). Pharmacologic agents that modulate the release of mediators from mast cells has helped to elucidate the biochemical mechanisms by which immunological and non-immunological stimuli activate these cells. Furthermore, the study of surface receptors and signaling pathways associated with mast cell activation revealed novel pharmacologic targets. Thus, the development of pharmacologic agents based on this new wave of knowledge holds promise for the treatment of several mast cell-mediated disorders.