| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2530089 | Current Opinion in Pharmacology | 2012 | 7 Pages |
Abstract
The zebrafish has attracted interest from both the scientific and general press owing to its transition from a model of developmental biology to a tool for biomedical and preclinical studies. In this brief review, we summarise the advantages of a unique model organism and outline some of its recent contributions to the understanding of vascular development and remodelling.
► Zebrafish are small, cheap, and easy to maintain. ► Zebrafish embryos develop independently, are transparent and extremely genetically tractable. ► Transgenic zebrafish allow in vivo vascular imaging that outclasses other models. ► Angiogenesis is well-conserved; insights from zebrafish are relevant to humans.
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Authors
Nicholas M Quaife, Oliver Watson, Timothy JA Chico,