| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2530154 | Current Opinion in Pharmacology | 2011 | 7 Pages |
Abstract
5-HT4 receptors control brain physiological functions such as learning and memory, feeding and mood behaviour as well as gastro-intestinal transit. 5-HT4 receptors are one of the 5-HT receptors for which the available drugs and signalling knowledge are the most advanced. Several therapeutic 5-HT4 receptor drugs have been commercialized. Therefore, the hope that 5-HT4 receptors could also be the target for brain diseases is reasonable. Several major devastating illnesses could benefit from 5-HT4 receptors-directed therapy such as Alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders.
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Authors
Joël Bockaert, Sylvie Claeysen, Valérie Compan, Aline Dumuis,