| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2530248 | Current Opinion in Pharmacology | 2010 | 6 Pages |
Abstract
Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating lipolysis in adipose tissue and fatty acid oxidation. Brown adipocyte development within white adipose tissue of humans suggests that mouse models may be applicable to human obesity. Consequently, new therapies should target adipose tissue to specifically reduce fat mass through controlled triglyceride utilization.
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Authors
Genevieve Marcelin, Streamson Chua Jr,