| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2530718 | Current Opinion in Pharmacology | 2006 | 7 Pages |
Abstract
Although the presence of functional GABAB receptors in mammalian brain has been known for more than 20 years, there is still only one therapeutic agent in use, baclofen, which mediates its effects directly via this receptor. However, activation of this receptor can produce numerous effects that might be amenable to drug development. Evidence from preclinical studies also suggests that antagonism of the GABAB receptor produces beneficial clinical effects.
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Authors
Norman G Bowery,