Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2531064 | European Journal of Pharmacology | 2016 | 6 Pages |
Abstract
Basophils are functionally closely related to mast cells. Both cell types express the high-affinity IgE receptor (FcεRI) and rapidly release preformed mediator from intracellular stores upon IgE-mediated activation. However, in contrast to mast cells basophils finish their maturation in the bone marrow and have a lifespan of only 2–3 days. Basophil numbers increase in response to IL-3 or TSLP and migrate into tissues to promote type 2 immune responses. Here we review recent advances regarding the pro- and anti-inflammatory functions of basophils in murine models and human allergic inflammation of the skin, lung and intestine.
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Authors
Christian Schwartz, Joerg U. Eberle, David Voehringer,