Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2536230 | European Journal of Pharmacology | 2007 | 4 Pages |
Abstract
The effect of methylprednisolone on the hydrolysis of adenine nucleotides by rat blood serum enzymes was studied. Adult male Wistar rats were submitted to three different treatments with synthetic steroid methylprednisolone: one dose of 50Â mg/kg, i.p. (acute); or oral doses of 6Â mg/kg dissolved in drinking water for 15 (sub-chronic) or 30 (chronic) days. Decreased ADP hydrolysis was observed after acute and sub-chronic treatments. Furthermore, ATP, ADP and AMP hydrolysis decreased after chronic treatment. These alterations may constitute one of the mechanisms that mediate the development of some of the side effects associated with corticosteroid use.
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Authors
Iraci Lucena S. Torres, Cristina Ribas Fürstenau, Gabriela Rossi, Eliane Dallegrave, Gustavo Dallegrave, Barbara Stenzel, Giovana Dantas, Ana Maria O. Battastini, João J.F. Sarkis, Maria Beatriz C. Ferreira,