Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2536517 | European Journal of Pharmacology | 2007 | 4 Pages |
Abstract
Gaseous mediators such as nitric oxide (NO) play a major regulatory role in the cardiovascular system homeostasis, including platelet aggregation. Here, we investigated whether hydrogen sulfide (H2S), a newly recognized endogenous mediator, can affects aggregation of human platelets, using sodium hydrogen sulfide (NaHS) as H2S-donor. NaHS inhibited platelet aggregation induced by ADP, collagen, epinephrine, arachidonic acid, thromboxane mimetic, U46619, and thrombin. H2S effect was not dependent by cAMP/cGMP generation, NO production or potassium-channels opening. NaHS concentrations (up to 10 mM) did not exert toxic effects on platelet viability. The possible protective role of endogenous H2S in cardiovascular system is discussed.
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Authors
Giovanni Zagli, Riccardo Patacchini, Marcello Trevisani, Rosanna Abbate, Sandro Cinotti, Gian Franco Gensini, Giulio Masotti, Pierangelo Geppetti,