| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2536751 | European Journal of Pharmacology | 2006 | 4 Pages |
Abstract
By comprehensive and detailed measurement of the time course of withdrawal signs in rats, Joyce et al. (J. Theo. Biol. 240:531–537, 2006) recently provided a creative quantitative model of the onset of drug dependence based on the requirement of protein synthesis. Because the initial model fit the data imperfectly over the full time course, those authors postulated that additional features would be needed. We report excellent fit of the data (R2 = 0.96) by adding: (1) a transient early phase, and (2) a delay in the buildup of protein.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Robert B. Raffa, Ronald J. Tallarida,