Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2536885 | European Journal of Pharmacology | 2006 | 4 Pages |
Abstract
In rats receiving bilateral femoral arteries ligation (day 0), repeated oral administration of the prostacyclin derivative beraprost sodium (50 μg/kg, b.i.d.) from day 1 to day 5 resulted in a significant prolongation in walking time in rotarod walking exercise performed on day 5. Similarly, results were obtained in rats with bilateral femoral arterial thrombosis induced by application of FeCl3/HCl. In the ligation model, a significant increase was observed in femoral/carotid arterial blood pressure ratio even on day 2. These results indicated that beraprost sodium improves blood flow and walking disturbances associated with arterial occlusion in rats.
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Authors
Mitsuko Miyamoto, Toshikazu Tayama, Sin'ichi Yamaguchi, Masayuki Kaneko, Hajimu Kurumatani,