Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2536928 | European Journal of Pharmacology | 2006 | 7 Pages |
The nuclear transcription factors κB (NF-κB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-κB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-κB in regulating neuron survival in pathological conditions. A recent progress in understanding the mechanisms responsible for opposite effects elicited by NF-κB in brain dysfunctions arises from the identification of diverse NF-κB complexes specifically involved in the mechanism of neuronal cell death or cell survival. We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-κB complexes for the treatment of neurodegenerative disorders and memory dysfunctions.