| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2537073 | European Journal of Pharmacology | 2006 | 5 Pages |
Abstract
We have evaluated the effects of the acute administration of noncompetitive N-methyl-d-aspartate receptor antagonist, ketamine, on the expression of serine racemase and d-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and d-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-d-aspartate receptors.
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Authors
Kazuhide Takeyama, Masanobu Yoshikawa, Tetsuo Oka, Mitsuru Kawaguchi, Toshiyasu Suzuki, Atsushi Hashimoto,