Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2537284 | European Journal of Pharmacology | 2006 | 5 Pages |
Abstract
For in vitro experiments, the enzyme activity increased at 0.02Â mM and decreased at 0.08Â mM melatonin concentration and reached a plateau above 0.08Â mM. Melatonin was administered 10Â mg/kg intraperitoneally (ip) and had a stimulatory effect on the enzyme. In vivo studies were performed for melatonin in Sprague-Dawley rats and time-dependent effects were demonstrated. Glutathione reductase activity in erythrocytes was increased more by melatonin at 1 and 3Â h. These results indicate that pharmacological levels of melatonin increased enzyme activity in erythrocytes. They also indicate that melatonin may be pharmacologically useful in patients with a deficiency of the enzyme in red blood cells causing hemolytic anemia.
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Authors
Mustafa Erat, Mehmet Ciftci,