Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2537480 | European Journal of Pharmacology | 2006 | 4 Pages |
Abstract
The purpose of the present study was to elucidate the brain regions in which citalopram, a selective serotonin reuptake inhibitor (SSRI), exerts its anxiolytic effects in conditioned fear stress (CFS) in rats, an animal model of anxiety. The effect of citalopram on CFS-induced c-Fos expression was investigated using immunohistochemistry. Systemic administration of citalopram attenuated contextual CFS-induced c-Fos expression in the secondary motor cortex, primary somatosensory cortex, and basolateral nucleus of the amygdala. Among these regions the basolateral nucleus of the amygdala is a likely candidate region in which citalopram exerts its anxiolytic effect.
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Authors
Takeshi Izumi, Takeshi Inoue, Yuji Kitaichi, Shin Nakagawa, Tsukasa Koyama,