The latex sap of the ‘Old World Plant’ Lagenaria siceraria with potent lectin activity mitigates neoplastic malignancy targeting neovasculature and cell death

•The latex sap of dietary Lagenaria siceraria (LSL) with potent lectin activity exerts Immunopotentiating activity.•LSL regresses tumor cell proliferation both in-vitro and in-vivo tumor models.•LSL inhibits the progression of tumor by targeting apoptosis and tumoral neovasculature through altered gene expression.

Lifestyle and dietary modifications have contributed much to somatic genetic alteration which has concomitantly led to increase in malignant diseases. Henceforth, plant based and dietary interventions to mitigate and impede oncogenic transformation are in great demand. We investigated the latex sap (LSL) of the dietary Lagenaria siceraria vegetable, the first domesticated plant species with the potent lectin activity for its functional role against the tumor progression and its mechanism. LSL has markedly stimulated proliferation of lymphocytes and displayed strong cytotoxic activity against cancer both in-vitro and in-vivo. The tumor regression was paralleled with drastic reduction in tumoral neovasculature as evidenced from angiogenic parameters and abrogated related gene expressions. LSL has also triggered apoptotic signaling cascade in cancer cells through activation of caspase-3 mediated activation of endonuclease and inducing apoptotic cellular events. Collectively our study provides tangible evidences that latex sap from L. siceraria with immunopotentiating ability significantly regresses the tumor progression by targeting angiogenesis and inducing cell death.

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