| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2540661 | International Immunopharmacology | 2015 | 7 Pages |
•Serum S100B level may be correlated with the CO poisoning.•Serum S100B level may be effective biomarker for CO poisoning.•Serum S100B level can be used for diagnosing for CO poisoning.•CO poisoning patients presented with a high serum S100B level in Asians.•CO poisoning patients presented with a high serum S100B level in Caucasians.
ObjectiveTo investigate the correlation between serum S100B level and carbon monoxide (CO) poisoning by meta-analysis.MethodsBy searching both English and Chinese language-based electronic databases (PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wanfang databases, China national knowledge infrastructure (CNKI), VIP database, etc.) thoroughly, we tabulated and analyzed the collected data with the use of Comprehensive Meta-analysis 2.0 (CMA 2.0).ResultsTotally 108 studies have been searched initially (92 studies in Chinese, 16 studies in English). Nine case–control studies (4 studies in English, 5 in Chinese) were chosen for an updated meta-analysis including 542 patients with CO poising and 236 healthy controls. Results identified that the serum S100B level were obviously higher than that in healthy controls (SMD = 1.600, 95% CI = 1.055–2.145, P < 0.001). A subgroup based on the ethnicities revealed that the serum S100B level in Caucasian and Asian subgroups was clearly higher than serum S100B level in healthy controls (Asians: SMD = 2.0624, 95% CI = 1.736–3.511, P < 0.001; Caucasians: SMD = 0.447, 95% CI = 0.197–0.697, P < 0.001).ConclusionSerum S100B level may be correlated with the CO poisoning and could be effective biomarker for early diagnosis and treatment monitoring in CO poisoning.
