| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2540750 | International Immunopharmacology | 2015 | 8 Pages |
•This review focuses on mechanisms of individual IL-27 and IL-27 receptor subunits.•This review discusses the potential role of IL-27 as a clinical therapeutic target.•This review discusses advances of IL-27 regarding inflammation.•This review discusses advances of IL-27 regarding virus infections.•This review discusses advances of IL-27 regarding tumors.
Interleukin (IL)-27 is an important pleiotropic immunological regulator for having dual effects on the immune responses. Several distinct findings have been highlighted that in certain conditions, neutralizing IL-27 or its subunit IL-27p28 might be a useful strategy to limit inflammation. Recently more insights have revealed that IL-27 could also exert potent inhibitory functions in some other immune circumstances including virus infection and tumor immunity. In this review, we describe IL-27 receptor subunits and the mechanisms of individual IL-27, and summarize the advances of their preclinical application trials. In addition, the potential role of IL-27 as a clinical therapeutic target will also be discussed.
