Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2541953 | International Immunopharmacology | 2009 | 4 Pages |
Abstract
MicroRNAs (miRNAs)-mediated RNA interference are emerging as an important regulatory pathway for various biological processes, including development, differentiation, and homeostasis. Accumulated evidence suggests that miRNAs regulate T cell and B cell differentiation, proliferation, and apoptosis. Deletion of miRNAs in hematopoietic stem cells or in thymus disrupts T cell homeostasis and results in autoimmunity and abnormal cytokine production. Regulatory T cells are potent immune regulators. In this mini-review, we provide a brief overview of the important roles of miRNAs in the development and function of T cells, especially in immune regulatory T cells.
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Authors
Li Zhou, Kook Heon Seo, Henry K. Wong, Qing-Sheng Mi,