| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2542653 | International Immunopharmacology | 2006 | 6 Pages |
Abstract
EPS-1 is a novel extracellular polysaccharide produced by a strain of thermotolerant Bacillus licheniformis, isolated from a shallow marine hot spring of Vulcano Island (Italy). In this paper, antiviral and immunomodulatory effects of EPS-1 were evaluated. It was found that EPS-1 treatment impaired HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells.Since several cytokines modulate the immune response to viruses, Th1- and Th2-type cytokines were assayed in supernatants of PBMC in different experimental conditions.EPS-1 induced IL-12, IFN-γ, IFN-α, TNF-α and IL-18, but not IL-4. Thus, the antiviral effect of EPS-1 on PBMC seems to be related to the pattern of cytokines induced.
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Authors
Adriana Arena, Teresa L. Maugeri, Bernadette Pavone, Daniela Iannello, Concetta Gugliandolo, Giuseppe Bisignano,