| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2550945 | Life Sciences | 2015 | 5 Pages |
Epigenetics refers to functional alterations in gene expression or phenotype without any change of the underlying DNA sequence. It is the study of the potential of a cell or organism to express different traits through functional regulation of its gene transcription. Though it is met as a necessary process in biology, epigenetics may often play a crucial part in the development of specific pathologic conditions, including cardiovascular diseases and hypertension.
Graphical abstractHYPOmeth: hypo-methylation, HYPERmeth: hyper-methylation, SERPIN-A3: serine protease inhibitor A3, HSD11B2: hydroxysteroid dehydrogenase-11β2, RAS: renin–angiotensin–aldosterone, NKCC1: Na+-K−-2Cl cotransporter 1, PE: preeclampsia, nc-RNA: non-coding RNA, si-RNA: small interfering RNA, mi-RNA: micro RNA, DoT1: disruptor of telomeric silencing-1, ACE: angiotensin converting enzyme, CHD2: chromodomain-helicase-DNA-binding protein 2, H3, H4: histone 3, histone 4, NCC: Na+-Cl− cotransporter, ENaC: epithelial Na+ channel, H3K79: lysine 79 residue in H3.Figure optionsDownload full-size imageDownload high-quality image (170 K)Download as PowerPoint slide
